Season
- Season 2 2010-11-08
- Season 1 2009-11-09
Episode
- Episode 1: Janet Jackson
- Episode 2: Donald Elson, Kosta Trouva
- Episode 3: Howie Mandel, Juliette Lewis
- Episode 4: Denzel Washington, Hilary Duff
- Episode 5: Tom Felton, Ne-Yo
- Episode 6: David Arquette, Ashley Greene, Billy the Exterminator
- Episode 7: Billy Bob Thornton, Kunal Nayyar, Ice Cube
- Episode 8: Dwayne Johnson, Katie Cassidy
- Episode 9: Jennifer Love Hewitt
- Episode 10: Bill Cosby, Angela Kinsey, Atomic Tom
- Episode 11: Charles Barkley, Brandy, Cee-Lo Green
- Episode 12: Mario Lopez
- Episode 13: Khloe Kardashian, Jo Frost, Nicki Minaj
- Episode 14: Bob Saget, Nene Leakes, Keri Hilson
- Episode 15: Alan Cumming, Chris D'Elia
- Episode 16: Steve Harvey, the 88
- Episode 17: Eric Stonestreet, J.B. Smoove, Dov Davidoff
- Episode 18: Anna Faris, Apolo Anton Ohno, Natasha Bedingfield
- Episode 19: Mila Kunis, Dr. Drew Pinsky, Chrisette Michele
- Episode 20: Justin Timberlake, Stephen Dorff, Ciara
- Episode 21: Xzibit, a performance from Cirque Du Soleil's "Mystere"
- Episode 22: Gene Simmons, Scott Bakula, Bettye Lavette with the Ese Vatos
- Episode 23: Ron Artest, will.i.am, Dean Cole
- Episode 24: Jack Black, Hailee Steinfeld, Filter
- Episode 25: Lauren Graham, Will Sasso, Plain White T's
- Episode 26: Mary Lynn Rajskub, Maz Jobrani
- Episode 27: El Debarge featuring Faith Evans, Michael Bearden & the Ese Vatos
- Episode 28: David Duchovny, Kristen Schaal, Saving Abel
- Episode 29: Seth Rogen, Ginnifer Goodwin, Sick Puppies
- Episode 30: William H. Macy, Camille Grammer, Cali Swag District
- Episode 31: Cameron Diaz, Jason Priestley, Luke Perry, Greg Fizsimmons
- Episode 32: Bill Engvall, Johnny Weir, My Chemical Romance
- Episode 33: Ashley Tisdale, Kevin Hart, Grace Potter & the Nocturnals
- Episode 34: Vanessa Williams, Shorty Rossi
- Episode 35: Jason Statham, Busy Philipps, Wiz Khalifa
- Episode 36: Jennifer Love Hewitt, Guy Fieri
- Episode 37: Kristen Bell, Jake Johnson, Slash
- Episode 38: DeSean Jackson, the Thermals
- Episode 39: Mindy Kaling, Derek Fisher, Jasper Redd, Arturo Sandoval
- Episode 40: Billy Gardell, Rachel Bilson, OK Go
- Episode 41: Jamie Foxx, Aubrey Plaza
- Episode 42: Channing Tatum, Margaret Cho, 50 Cent with Governor
- Episode 43: Joan Rivers, Greg Jennings, Baron Vaughn
- Episode 44: Brad Womack, Taylor Momsen, the Pretty Reckless
- Episode 45: R. Kelly, Paul Wesley, James Loney, Bobby Castillo, Tommy Davis, Kenny Landreaux, Rudy Law, Steve Lyons, Don Mattingly
- Episode 46: Justin Bieber, Far East Movement
- Episode 47: Liam Neeson, a performance by the Broadway cast of "Rock of Ages"
- Episode 48: 200th Episode - Jenni "JWoww" Farley, Jim Jefferies
- Episode 49: Amar'e Stoudemire, Kate Gosselin, Sebastian Maniscaclo
- Episode 50: Martin Lawrence, Jared Leto, 30 Seconds to Mars
- Episode 51: Forest Whitaker, Jessica Lucas, Bobby V & Bobby Brown
- Episode 52: Jason Biggs, Anne Heche
- Episode 53: Owen Wilson, Aly Michalka, Terry Fator
- Episode 54: Cheryl Burke, Brandon T. Jackson, John Popper & the Duskray Troubadours
- Episode 55: Ron Artest, DJ Pauly D, Michelle Rodriguez, Future Funk
- Episode 56: Topher Grace, Scott Disick, Cake
- Episode 57: Forest Whitaker, Donald Glover, Steel Train
- Episode 58: Aaron Eckhart, Malin Akerman, Eric Andre
- Episode 59: Curtis Stone, Lupe Fiasco
- Episode 60: Pee-wee Herman, Emanuelle Chriqui
- Episode 61: Mike Tyson, Emmy Rossum, 30 Seconds to Mars
- Episode 62: Jim Rome, Boney James
- Episode 63: Matthew McConaughey, Micky Ward, Ron Artest featuring George Lopez, Fat Joe, B Real, Lenny and Max from Aventura and Taz
- Episode 65: Bethenny Frankel, D.L. Hughley, Seether
- Episode 66: Vanessa Hudgens, Sergio Mendes
- Episode 67: Larry King, Brent Weinbach
- Episode 68: Snoop Dogg, Brittany Snow
- Episode 69: Lil Jon, Panic! At The Disco
- Episode 70: Drew Carey, Sarah Shahi, Quinn Dahle
- Episode 71: Lisa Lampanelli
- Episode 72: Danny McBride, Camilla Luddington, Avril Lavigne
- Episode 124: Kathy Griffin, Tom Felton
Lopez Tonight Season 2 Howie Mandel, Juliette Lewis
Lopez Tonight is an American late-night television talk show that was hosted by comedian George Lopez. The hour-long program premiered on November 9, 2009, on cable network TBS. Lopez was the first Mexican American to host a late-night talk show on an English-language network in the United States. The show featured audience interaction using a high-energy format. The program aired Monday through Thursday at midnight Eastern and Pacific, immediately following Conan. On August 10, 2011, TBS announced Lopez Tonight would be cancelled. The final episode aired the following night.
